منابع مشابه
Genetics of Inflammatory Bowel Diseases.
In this review, we provide an update on genome-wide association studies (GWAS) in inflammatory bowel disease (IBD). In addition, we summarize progress in defining the functional consequences of associated alleles for coding and noncoding genetic variation. In the small minority of loci where major association signals correspond to nonsynonymous variation, we summarize studies defining their fun...
متن کاملGenetics of inflammatory bowel diseases--past, present, and future.
In this review, the evidence to support the multifactorial and polygenic nature of the disease is briefly described. The past of genetics of inflammatory bowel disease (IBD) is characterized by unfulfilled promises and is now closed with a new vision and a new promise coming from a genetic epidemiology approach. The genome-wide screening has led to the first gene of IBD and has given a new insi...
متن کاملGenetics of inflammatory bowel disease.
1. The aetiology of the chronic inflammatory bowel diseases, Crohn's disease and ulcerative colitis, is uncertain. Studies of specific environmental factors and immune dysfunction have provided little insight into disease pathogenesis. 2. Concordance rates in twin pairs and siblings provide strong evidence that genetic factors are important in disease pathogenesis. In Oxford, information was ob...
متن کامل[Inflammatory bowel diseases]
OBJECTIVE: To present a review about inflammatory bowel diseases in childhood so that pediatricians become familiar with two diseases (ulcerative colitis and Crohn s disease) that are increasing in incidence. METHODS: Articles of specific gastroenterological journals were analyzed. Information was also obtained from the author s extensive professional experience in the area. RESULTS: The two di...
متن کاملInflammatory bowel diseases.
All rights reserved. Unless special permission in writing is obtained, no part of this publication may be reproduced, stored in a retrieval system, or be transmitted in any form or by any means, electronic, mechanical, photocopying or otherwise. The material contained in this issue was submitted as previously unpublished material, except in the instances in which credit has been given to the so...
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ژورنال
عنوان ژورنال: Gastroenterology
سال: 2015
ISSN: 0016-5085
DOI: 10.1053/j.gastro.2015.08.001